Dr. Yi Charlie Chen
Professor of Biology
Dr. Yi Charlie Chen, professor of biology, has taught at Alderson Broaddus University since 2000. He received his Bachelor of Science and Master of Science degrees from Zhejiang University in China. He then received his second Master of Science degree and a Doctoral degree from Washington State University. Prior to coming to A-B, Dr. Chen worked as postdoctoral fellow at USDA and Oklahoma State University.
Dr. Chen has published over 56 different papers and book chapters in a wide range of scientific journals and books. In collaboration with professors at West Virginia University and Marshall University, Dr. Chen is currently working on molecular biology of cancer research. His research has focused on the inhibition of anti-cancer drugs, especially natural compounds, on angiogenesis: the growth of blood vessels that provide nutrients to cancer cells and are essential for tumor growth. The natural compounds Dr. Chen is currently studying include kaempferol, theaflavin, nobiletin, baicalin, baicalein, gallic acid, galangin, myricetin from plants, and chaetoglobosin K from a fungus. Dr. Chen is also working on nanochemoprevention using nanoparticles as a novel approach for cancer control. His group is currently studying the use of the nanotechnology to specifically target cancer cells using natural compounds. Together with scientists in USDA, Oklahoma State University and Washington State University, Dr. Chen also worked on developing DNA markers for detecting parasitism and predation. Dr. Chen has received several major grants over one million dollars from the National Institute of Health (NIH) and WV-INBRE, National Science Foundation (NSF) and WV-EPSCoR, Washington State Fruit Tree Commission, and USDA for scientific research. One of the grant Dr. Chen received in the amount of $500,000, it is the largest grant ever awarded to Alderson Broaddus for research.
Dr. Chen has also been nominated for the West Virginia Professor of the Year Award, a statewide award that honors the best teachers in West Virginia higher education. Dr. Chen is the recipient of the Faculty of the Year Award in 2013 selected by Alderson Broaddus students. Dr. Chen was the speaker for the 2013 ABU’s Opening Convocation. He was also the featured professor in the 2013 spring issue of the Neuron: West Virginia Journal of Science and Research. Dr. Chen has been selected as the plenary speaker, keynote speaker, and session chair in different scientific conferences.
Dr. Chen is currently serving as the Editor-in-Chief for a scientific journal: Journal of Nutritional Medicine and Diet Care. He also served as the Editor-in-Chief for The Open Entomology Journal between 2012-2015. He also serves as the Editorial Board Member for several scientific journals: Journal of Biochemistry and Molecular Biology Research, Journal of Nutritional Medicine and Diet Care, SM Journal of Environmental Toxicology, Austin journal of cancer and clinical research, and International Archives of Clinical Pharmacology. Dr. Chen also currently serves on the steering committee of West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE) and the Science Advisory Board.
Dr. Chen’s courses include: microbiology, genetics, evolution, research methods, parasitology, immunology, cell biology, and conservation biology. He has also engaged in global study in China regarding issues in sciences and cell biology.
Recent Publications (selected from a total of 61 peer-reviewed publications)
- Gao Y, Rankin GO, Tu Y, Chen YC. 2016. Theaflavin-3,3’-digallate decreases human ovarian carcinoma OVCAR-3 cell-induced angiogenesis via Akt and NOTCH-1 pathways, not via MAPK pathways. Int J Oncol. 48: 281-292.
- He Z, Chen AY, Rojanasakul Y, Rankin GO, Chen YC. 2016. Gallic acid, a phenolic compound, exerts anti-angiogenesis effects via PTEN-AKT- HIF-1α-VEGF signaling pathway in ovarian cancer cells. Oncology Reports 35: 291-297. PMID: 26530725.
- Luanpitpong S, Li J, Manke A, Brundage K, Ellis E, McLaughlin SL, Angsutararux P, Chanthra N, Voronkova M, Chen YC, Wang L, Chanvorachote P, Pei M, Issaragrisil S, Rojanasakul Y. 2015. SLUG is required for SOX9 stabilization and functions to promote cancer stem cells and metastasis in human lung carcinoma. Oncogene [Epub ahead of print] PMID: 26387547.
- Huang H, Chen AY, Ye X, Li, B, Rojanasakul Y, Rankin GO, Chen YC. 2015. Myricetin inhibits proliferation of cisplatin-resistant cancer cells through a p53-dependent apoptotic pathway. Int J Oncol. 47: 1494-1502. PMID: 26315556.
- Huang H, Chen AY, Rojanasakul Y, Ye X, Rankin GO, Chen YC. 2015. Dietary compounds galangin and myricetin suppress ovarian cancer cell angiogenesis. Journal of Functional Foods 15: 464-475. PMID: 26113875.
- Block K et al. 2015. Designing a broad-spectrum integrative approach for cancer prevention and treatment. Semin Cancer Biol. 35: S276-S304. PMID: 26590477.
- Chen J, Chen AY, Huang H, Ye X, Rollyson WD, Perry HE, Brown KC, Rojanasakul Y, Rankin GO, Dasgupta P, Chen YC. 2015. The flavonoid nobiletin inhibits tumor growth and angiogenesis of ovarian cancers via the Akt pathway. Int J Oncol. 46: 2629-2638. PMID: 25845666.
- Wang Z, Dabrosin C, Yin X, Fuster MM, Arreola A, Rathmell WK, Generali D, Nagaraju GP, El-Rayes B, Ribatti D, Chen YC, et al. 2015. Broad targeting of angiogenesis for cancer prevention and therapy. Semin Cancer Biol. 35: S224-243. PMID: 25600295.
- Wang X., Chen YC, Li B. 2015. Aligning 3D nanofibrous networks from self-assembled phenylalanine nanofibers. RSC Advances 5: 8022-8027. PMID: 25621167.
- He Z, Li B, Rankin GO, Rojanasakul Y, Chen YC. 2015. Selecting bioactive phenolic compounds as potential agents to inhibit proliferation and VEGF expression in human ovarian cancer cells. Oncology Letters 9(3): 1444-1450. PMID: 25663929.
- Li B, Gao Y, Rankin GO, Rojanasakul Y, Cutler SJ, Tu Y, Chen YC. 2015. Chaetoglobosin K induces apoptosis and G2 cell cycle arrest through p53-dependent 1 pathway in cisplatin-resistant ovarian cancer cells. Cancer Letters 356: 418-33. PMID: 25304379.
- Chen J., Creed A, Chen AY, Huang H, Li Z, Rankin GO, Ye X, Xu G, Chen YC. 2014. Nobiletin suppresses cell viability through AKT pathways in PC-3 and DU-145 prostate cancer cells. BMC Pharmacology and Toxicology 15(1): 59. PMID: 25342300.
- Luanpitpong S., Wang L, Stueckle TA, Tse W, Chen YC, Rojanasakul Y. 2014. Caveolin-1 regulates lung cancer stem-like cell induction and p53 inactivation in carbon nanotube-driven tumorigenesis. Oncotarget 5(11): 3541-3554. PMID: 24939878.
- Lohcharoenkal W, Wang L, Chen YC, Rojanasakul Y. 2014. Protein Nanoparticles as Drug Delivery Carriers for Cancer Therapy. BioMed Research International 2014: 180549. PMID: 24772414.
- Gao Y, Li W, Jia L, Li B, Chen YC, Tu Y. 2013. Enhancement of (−)-epigallocatechin-3-gallate and theaflavin-3-3′-digallate induced apoptosis by ascorbic acid in human lung adenocarcinoma SPC-A-1 cells and esophageal carcinoma Eca-109 cells via MAPK Pathways. Biochemical and Biophysical Research Communications 438(2): 370-374. PMID: 23892041.
- Luo H, Li B, Li Z, Cutler SJ, Rankin GO, Chen YC. 2013. Chaetoglobosin K inhibits tumor angiogenesis through downregulation of vascular epithelial growth factor-binding hypoxia-inducible factor 1a. Anticancer Drugs 24(7): 715-724. PMID: 23695013.
- Chen AY, Chen YC. 2013 A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention. Food Chemistry 138:2099-2107. PMID: 23497863.
- Brown KC, Perry HE, Lau JK, Jones DV, Pulliam JF, Thornhill BA, Crabtree CM, Luo H, Chen YC,Dasgupta P. 2013. Nicotine induces the upregulation of the alpha7-nicotinic receptor (α7-nAChR) in human squamous cell lung cancer cells via the Sp1/GATA pathway. J Biol Chem. 288: 33049-33059. PMID: 24089524
- Lau JK, Brown KC, Thornhill BA, Crabtree CM, Dom AM, Witte TR, Hardman WE, McNees CA, Stover CA, Carpenter AB, Luo H, Chen YC, Shiflett BS, Dasgupta P. 2013. Inhibition of cholinergic signaling causes apoptosis in human bronchioalveolar carcinoma. Cancer Research 73(4):1328-39. PMID: 23222296.
- Chen J, Li Z, Chen AY, Ye X, Luo H, Rankin GO, Chen YC. 2013. Inhibitory Effect of Baicalin and Baicalein on Ovarian Cancer Cells. Int J Mol Sci. 14(3): 6012-6025. PMID: 23502466.
- Chen, AY, YC Chen. 2013. Multipotent Flavonoid Kaempferol: Molecular Targets and Mechanism of Action and Nanotechnology applications in Cancer and Human Health. P. 171-186. In G. Villers & Y. Fougere (Ed.) “Kaempferol: Chemistry, Natural Occurrences and Health Benefits”. Nova Publishers, Hauppauge NY.
- Luo H, Jiang B, Li B, Li Z, Jiang B, Chen YC. 2012 Kaempferol Nanoparticles Achieve Strong and Selective Inhibition of Ovarian Cancer Cell Viability. International Journal of Nanomedicine 7:3951-3959. PMID: 22866004.
- Brown KC, Lau JK, Dom AM, Witte TR, Luo H, Crabtree CM, Shah YH, Shiftett BS, Marcelo AJ, Hardman WE, Egleton RD, Proper NA, Chen YC, Mangiarua EI, Dasgupta P. 2012. MG624, an alpha7-nAChR antagonist, inhibits angiogenesis via the Egr-1/ FGF2 pathway. Angiogenesis 15:99-114, PMID: 22198237.
- Luo H, Rankin GO, Juliano N, Jiang B, Chen YC. 2012. Kaempferol Inhibits VEGF Expression and In Vitro Angiogenesis through a novel ERK-NFkB-cMyc-p21 Pathway. Food Chemistry 130: 321-328. PMID: 21927533.