Faculty & Staff

Dr. Yi Charlie Chen

Dr. Yi Charlie Chen, professor of biology, has taught at Alderson Broaddus University since 2000. He received his Bachelor of Science and Master of Science degrees from Zhejiang University in China. He then received his second Master of Science degree and a Doctoral degree from Washington State University.  Prior to coming to A-B, Dr. Chen worked as postdoctoral fellow at USDA and Oklahoma State University.

Dr. Chen has published over 48 different papers and book chapters in a wide range of scientific journals and books. In collaboration with professors at West Virginia University and Marshall University, Dr. Chen is currently working on molecular biology of cancer research. His research has focused on the inhibition of anti-cancer drugs, especially natural compounds, on angiogenesis: the growth of blood vessels that provide nutrients to cancer cells and are essential for tumor growth. The natural compounds Dr. Chen is currently studying include kaempferol, nobiletin, baicalin, baicalein, gallic acid from plants, and chaetoglobosin K from a fungus. Dr. Chen is also working on nanochemoprevention using nanoparticles as a novel approach for cancer control. His group is currently studying the use of the nanotechnology to specifically target cancer cells using natural compounds. Together with scientists in USDA, Oklahoma State University and Washington State University, Dr. Chen also worked on developing DNA markers for detecting parasitism and predation. Dr. Chen has received several major grants over one million dollars from the National Institute of Health (NIH) and WV-INBRE, National Science Foundation (NSF) and WV-EPSCoR, Washington State Fruit Tree Commission, and USDA for scientific research. One of the grant Dr. Chen received in the amount of $500,000, it is the largest grant ever awarded to Alderson Broaddus for research.

Dr. Chen has also been nominated for the West Virginia Professor of the Year Award, a statewide award that honors the best teachers in West Virginia higher education. Dr. Chen is the recipient of the Faculty of the Year Award in 2013 selected by Alderson Broaddus students. Dr. Chen was the speaker for the 2013 ABU’s Opening Convocation. He was also the featured professor in the 2013 spring issue of the Neuron: West Virginia Journal of Science and Research. Dr. Chen has been selected as the plenary speaker, keynote speaker, and session chair in different scientific conferences.

Outside the College, Dr. Chen serves on the steering committee of West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE) and the Science Advisory Board. He also currently serves as the editor-in-Chief for The Open Entomological Journal by Bentham Science Publishers.

Dr. Chen’s courses include: microbiology, genetics, evolution, research methods, parasitology, immunology, cell biology, and conservation biology.  He has also engaged in global study in China regarding issues in sciences and cell biology.

Publications (selected from a total of 48 peer-reviewed publications)

1. Lohcharoenkal, W., L. Wang, Y. C. Chen and Y. Rojanasakul. 2014. Protein Nanoparticles as Drug Delivery Carriers for Cancer Therapy. BioMed Research International 2014: 180549.

2. Chen, AY, YC Chen. 2013. Multipotent Flavonoid Kaempferol: Molecular Targets and Mechanism of Action and Nanotechnology applications in Cancer and Human Health. P. 171-186. In G. Villers & Y. Fougere (Ed.) “Kaempferol: Chemistry, Natural Occurrences and Health Benefits”. Nova Publishers, Hauppauge NY.

3. Gao, Y., W. Li, L. Jia, B. Li, Y. C. Chen, Y, Tu. 2013. Enhancement of (−)-epigallocatechin-3-gallate and theaflavin-3-3′-digallate induced apoptosis by ascorbic acid in human lung adenocarcinoma SPC-A-1 cells and esophageal carcinoma Eca-109 cells via MAPK Pathways. Biochemical and Biophysical Research Communications 438(2): 370-374. PMID: 23892041.

4. Luo, H., B. Li, Z. Li, S. J. Cutler, G. O. Rankin, Y. C. Chen. 2013. Chaetoglobosin K inhibits tumor angiogenesis through downregulation of vascular epithelial growth factor-binding hypoxia-inducible factor 1a. Anticancer Drugs 24(7): 715-724. PMID: 23695013.

5. Chen, A. Y., and Y. C. Chen. 2013 A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention. Food Chemistry 138:2099-2107. PMID: 23497863.

6. Brown KC, Perry HE, Lau JK, Jones DV, Pulliam JF, Thornhill BA, Crabtree CM, Luo H, Chen YC,Dasgupta P. 2013. Nicotine induces the upregulation of the alpha7-nicotinic receptor (α7-nAChR) in human squamous cell lung cancer cells via the Sp1/GATA pathway. J Biol Chem. Oct 2. [Epub ahead of print] PMID: 24089524

7. Lau JK, Brown KC, Thornhill BA, Crabtree CM, Dom AM, Witte TR, Hardman WE, McNees CA, Stover CA, Carpenter AB, Luo H, Chen YC, Shiflett BS, Dasgupta P. 2013. Inhibition of cholinergic signaling causes apoptosis in human bronchioalveolar carcinoma. Cancer Research 73(4):1328-39. PMID: 23222296.

8. Chen, J., Z. Li, A. Y. Chen, X. Ye, H. Luo, G. O. Rankin, Y. C. Chen. 2013.  Inhibitory Effect of Baicalin and Baicalein on Ovarian Cancer Cells. Int J Mol Sci. 14(3): 6012-6025. PMID: 23502466.

9. Luo, H., B. Jiang, B. Li, Z. Li, B. Jiang, and Y. C. Chen. 2012 Kaempferol Nanoparticles Achieve Strong and Selective Inhibition of Ovarian Cancer Cell Viability. International Journal of Nanomedicine 7:3951-3959. PMID: 22866004.

10. Brown, K. C., Lau, J. K., Dom, A. M., Witte, T. R., Luo, H., Crabtree, C. M., Shah, Y. H., Shiftett, B. S., Marcelo, A. J., Hardman, W.E., Egleton, R. D., Proper, N. A., Chen, Y. C., Mangiarua, E. I. and Dasgupta, P. 2012. MG624, an alpha7-nAChR antagonist, inhibits angiogenesis via the Egr-1/ FGF2 pathway., Angiogenesis 15:99-114, PMID: 22198237.

11. Luo, H., G. O. Rankin, N. Juliano, B. Jiang, and Y. C. Chen. 2012. Kaempferol Inhibits VEGF Expression and In Vitro Angiogenesis through a novel ERK-NFkB-cMyc-p21 Pathway. Food Chemistry 130: 321-328. PMID: 21927533.

12. Luo, H., G. O. Rankin, S. Straley, and Y. C. Chen. 2011. Prolonged Incubation and Stacked Film Exposure Improve Sensitivity in Western Blotting. Journal of Pharmacological and Toxicological Methods. 64: 233-237. PMID: 21741488.

13. Luo, H., G. O. Rankin, Z. Li, L. DePriest, and Y. C. Chen. 2011. Kaempferol Induces Apoptosis in Ovarian Cancer Cells through Activating p53 in the Intrinsic Pathway. Food Chemistry 128:513-519. PMID: 21625365.

14. Luo, H., M. K. Daddysman, G. O. Rankin, B. Jiang, and Y. C. Chen. 2010. Kaempferol Enhances Cisplatin's Effect on Ovarian Cancer Cells through Promoting Apoptosis caused by Down Regulation of cMyc. Cancer Cell International 10:16. PMCID: PMC2885998.

15. Brown, K. C., T. R. Witte, W. E. Hardman, H. Luo, Y. C. Chen, A. B. Carpenter, J. K. Lau, and P. Dasgupta. 2010. Capsaicin Displays Anti-proliferative Activity against Human Small Cell Lung Cancer in Cell Culture and Nude Mice Models via the E2F Pathway. PLoS ONE 5(4) e10243. PMCID: PMC2857654.

16. Luo, H., G. O. Rankin, L. Liu, M. K. Daddysman, B. Jiang, and Y. C. Chen. 2009. Kaempferol Inhibits Angiogenesis and VEGF Expression through both HIF Dependent and Independent Pathways in Human Ovarian Cancer Cells. Nutrition and Cancer 61(4): 554-563. PMCID: PMC2770884.

17. Luo, H., B. Jiang, S. M. King, and Y. C. Chen. 2008. Inhibition of Cell Growth and VEGF Expression in Ovarian Cancer Cells by Flavonoids. Nutrition and Cancer 60(6): 800-809. PMID: 19005980.

18. Chen, Y., K. S. Pike, M. H. Greenstone, and K. A. Shufran. 2006. Molecular markers for identification of the hyperparasitoids Dendrocerus carpenteri and Alloxysta xanthopsis in Lysiphlebus testaceipes parasitizing cereal aphids. BioControl 51: 183-194.

19. Jones, D. B., K. L. Giles, Y. Chen, and K. A. Shufran. 2005. Estimation of hymenopteran parasitism in cereal aphids by using molecular markers.
J Econ Entomol. 98(1):217-21. PMID: 15765686

20. Fang, J., Z. Cao, Y. C. Chen, E Reed, and B. Jiang. 2004. 9-β-D-Arabinofuranosyl-2-fluoroadenine inhibits expression of vascular endothelial growth factor through hypoxia-inducible factor-1 in human ovarian cancer cells. Mol. Pharmacol. 66: 178-186. PMID: 15213310.

21. Chen, Y., K. L. Giles, M. E. Payton, and M. H. Greenstone. 2000. Identifying key cereal aphid predators by molecular gut analysis. Molecular Ecology 9: 1887-1898. PMID: 11091324